The details of these three Monte Carlo codes can be found in Gervais et al. Because the energy deposited is highly concentrated along the ion tracks in the case of C-ion irradiation, the distance between radicals is shorter and results in a higher recombination probability. Consequently, the decrease in the total number of hydroxyl radicals is greater for C-ions than for X-rays. For this reason, 10 —12 s corresponds to the minimum difference between X-rays and C-ions with regards to hydroxyl distribution.
This allowed us to consider a particular configuration of the mixed field and perform the three simulation stages presented above for each component. Taken together, our results contribute to the understanding of the underlying mechanisms of the radiation-dependent metastatic abilities of HNSCC-CSCs in a hypoxic tumor microenvironment and how this differs in response to C-ion irradiation compared with X-rays.
In addition, this work proposes a new paradigm setting ROS spatial distribution as one of the mechanisms with potentially high relevance to explain the differential responses to X-rays and C-ions for cell invasion and migration. The manuscript was revised by OLE English. Conceptualization: A. Read article at publisher's site DOI : Cancers Basel , 13 15 , 30 Jul Cancers Basel , 13 5 , 04 Mar Cited by: 0 articles PMID: Am J Cancer Res , 11 1 , 01 Jan Free to read.
Front Public Health , , 03 Feb This data has been text mined from the article, or deposited into data resources. To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation. Br J Cancer , 10 , 13 Apr Oncotarget , 7 30 , 01 Jul Cell Physiol Biochem , 44 5 , 11 Dec Cited by: 29 articles PMID: Walenta S , Mueller-Klieser W.
Front Oncol , , 25 Feb Mol Cancer , 16 1 , 30 Jan Contact us. Europe PMC requires Javascript to function effectively. Recent Activity. Search life-sciences literature Over 39 million articles, preprints and more Search Quick link: Coronavirus articles and preprints. Recent history Saved searches. Wozny AS 1 ,. Vares G 2 ,. Alphonse G 1 ,. Lauret A 1 ,. Monini C 3 ,.
Cuerq C 4 ,. Fujimori A 5 ,. Monboisse JC 6 ,. Beuve M 3 ,. Nakajima T 7 ,. Rodriguez-Lafrasse C 1. Affiliations 5 authors 1. Share this article Share with email Share with twitter Share with linkedin Share with facebook. Free full text. Cancers Basel. Published online Apr 3. PMID: Find articles by Alexandra Lauret. Find articles by Caterina Monini. Find articles by Michael Beuve.
Author information Article notes Copyright and License information Disclaimer. Received Feb 12; Accepted Apr 1. This article has been cited by other articles in PMC.
Go to:. Open in a separate window. Figure 1. Figure 2. Figure 3. Figure 4. Figure 5. Figure 6. Quantification of Motility and Cell Migration and Invasion Cell motility was quantified using a wound-healing assay. Western-blot Analyses After incubation in normoxia or for 6, 12, or 24 h under hypoxia, cells were lysed and the protein concentration was determined The simulation was composed of three different stages: The physical stage corresponds to a time period of 10 —15 s after the impact of each primary particle and leads to a distribution of excited and ionized water molecules and of low energy electrons.
Click here for additional data file. The cancer stem cell niche: Cross talk between cancer stem cells and their microenvironment. Tumour Biol. Moncharmont C. Targeting a cornerstone of radiation resistance: Cancer stem cell. Cancer Lett. Harris K. Stem Cells Int. Das B. Stem Cells. Schlaff C. Bringing the heavy: Carbon ion therapy in the radiobiological and clinical context.
Jin X. Carbon ions induce autophagy effectively through stimulating the unfolded protein response and subsequent inhibiting Akt phosphorylation in tumor cells. Fujita M. Carbon-ion radiation enhances migration ability and invasiveness of the pancreatic cancer cell, PANC-1, in vitro. Since vitamin E is a fat-soluble compound stored in AT, concentrations in AT may be a better indicator of long term intake than plasma levels.
Traber et al. This is in agreement with findings that some ABL patients on massive supplementation with vitamin E did achieve normal concentrations of AT tocopherol [ 8 , 39 ] and illustrates that changes in AT are very slow. Handelman et al.
This correlation coefficient was a bit lower than those reported by Mino et al. Su et al. These values will be useful to assess the vitamin E nutritional status of children in epidemiological studies or in particular diseases, such as primary hypocholesterolemia including CMRD, familial hypobetalipoproteinemia and abetalipoproteinemia. The biopsy of AT could be used at diagnosis to assess the severity of the vitamin E deficiency and periodically after a long duration of vitamin E therapy to assess whether the treatment is effective and achieves values close to normal.
However, AT biopsies are not useful for regular monitoring due to the very slow change of vitamin E concentrations in AT. Considering that platelet tocopherol concentrations are not influenced by lipids [ 35 ], reference values in children would have been relevant given that it is important to use more than one biomarker for tocopherol to evaluate the effectiveness of treatment in patients with severe hypocholesterolemia.
Moreover, it is not clearly established whether increased oxidative stress is seen in genetic hypocholesterolemia. The measurement of urinary F2-isoprostanes in healthy children and CMRD patients would probably have provided valuable information [ 44 ]. Vitamin E: antioxidant activity, biokinetics, and bioavailability.
Annu Rev Nutr. Zingg JM, Azzi A. Non-antioxidant activities of vitamin E. Curr Med Chem. Vitamin E in human health and disease. Crit Rev Clin Lab Sci. Guidelines for the diagnosis and management of chylomicron retention disease based on a review of the literature and the experience of two centers. Orphanet J Rare Dis. Update on primary hypobetalipoproteinemia. Curr Atheroscler Rep. Article PubMed Google Scholar.
Levy E. Insights from human congenital disorders of intestinal lipid metabolism. J Lipid Res. Tocopherol distribution and intracellular localization in human adipose tissue.
Am J Clin Nutr. Kayden HJ. Tocopherol content of adipose tissue from vitamin E-deficient humans. Ciba Found Symp. The measurement of nanograms of tocopherol from needle aspiration biopsies of adipose tissue: normal and abetalipoproteinemic subjects. Alpha-tocopherol adipose tissue stores are depleted after burn injury in pediatric patients.
Population-based study of alpha- and gamma-tocopherol in plasma and adipose tissue as biomarkers of intake in Costa Rican adults. Serum retinol, beta-carotene, alpha-tocopherol and cholesterol in healthy French children. Int J Epidemiol. Clin Biochem. International Conference on Harmonisation; guidance on E11 clinical investigation of medicinal products in the pediatric population; availability.
Fed Regist. Simultaneous measurement of seven carotenoids, retinol and alpha-tocopherol in serum by high-performance liquid chromatography. Simultaneous determination of alpha-tocopherol and retinol in plasma or red cells by high pressure liquid chromatography.
The theory of reference values. Part 5. Statistical treatment of collected reference values. Determination of reference limits. Clin Chim Acta. Google Scholar. Determinants of plasma retinol, beta-carotene, and alpha-tocopherol during adolescence.
Int J Vitam Nutr Res. Factors influencing blood concentration of retinol, alpha-tocopherol, vitamin C, and beta-carotene in the French participants of the SU. MAX trial. Eur J Clin Nutr. The transport of alpha-tocopherol and beta-carotene in human blood. Traber MG, Jialal I. Measurement of lipid-soluble vitamins--further adjustment needed? Lipid, lipoprotein and apolipoprotein profiles in European adolescents and its associations with gender, biological maturity and body fat--the HELENA Study.
Int J Obes Lond. Article Google Scholar. The interest of cholesterol levels in young children. Study in a population of 4, children aged 4. Presse Med. Novel modeling of reference values of cardiovascular risk factors in children aged 7 to 20 years. Reference values of plasma and lipoprotein cholesterol and triacylglycerols in healthy children. Arch Fr Pediatr. The use of different lipids to express serum tocopherol: lipid ratios for the measurement of vitamin E status.
Vitamin C stability after baseline acidification was analysed up to 48 h. Changes observed were compared to a clinical cut-off defined as total change limit based on a combination of analytical performance and within-subject variation.
Results: Clinically and statistically significant changes occurred only in vitamins C Vitamin C in acidified serum conserved at room temperature appeared unstable.
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